Urolithin A

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population.

Singh Anurag (2022) · European journal of clinical nutrition · n=100

Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial.

Domínguez-López Inés (2025) · BMC medicine · n=1180

The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial.

Zelicha Hila (2022) · BMC medicine · n=294

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients.

Nuñez-Sánchez María A (2014) · Molecular nutrition & food research · n=52

A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance.

Jarrard David (2021) · The Prostate

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.

Singh Anurag (2022) · Cell reports. Medicine

Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients.

Ávila-Gálvez María Ángeles (2019) · Molecular nutrition & food research

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome.

Puupponen-Pimiä Riitta (2013) · Molecular nutrition & food research

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.

Yaskolka Meir Anat (2023) · BMC medicine · n=256

Urolithins are the main urinary microbial-derived phenolic metabolites discriminating a moderate consumption of nuts in free-living subjects with diagnosed metabolic syndrome.

Tulipani Sara (2012) · Journal of agricultural and food chemistry

Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome.

Mora-Cubillos Ximena (2015) · Molecular nutrition & food research

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).

Kaplan Alon (2022) · The American journal of clinical nutrition · n=284

Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial.

Istas Geoffrey (2018) · Archives of biochemistry and biophysics

Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial.

Jamialahmadi Tannaz (2024) · Reviews on recent clinical trials · n=10

Consumption of Watermelon Juice Enriched in l-Citrulline and Pomegranate Ellagitannins Enhanced Metabolism during Physical Exercise.

Martínez-Sánchez Ascensión (2017) · Journal of agricultural and food chemistry · n=19

Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals.

Haddad Ella H (2014) · Nutrition journal

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial.

Liu Sophia (2022) · JAMA network open · n=33

A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy.

Freedland Stephen J (2013) · Cancer prevention research (Philadelphia, Pa.) · n=33

Consumption of a Sourdough-Leavened Croissant Enriched with a Blend of Fibers Influences Fasting Blood Glucose in a Randomized Controlled Trial in Healthy Subjects.

Barone Lumaga Roberta (2024) · The Journal of nutrition