Berberine

The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized controlled trials.

Pirro Matteo (2016) · Pharmacological research · n=1670

Gender differences in the efficacy of pioglitazone treatment in nonalcoholic fatty liver disease patients with abnormal glucose metabolism.

Yan Hongmei (2021) · Biology of sex differences · n=185

Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endotelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial.

Trimarco Valentina (2015) · High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial.

Lei Lubi (2026) · JAMA network open · n=337

Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis.

Zhao Han (2021) · Reproductive health · n=1079

Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis.

Liang Yaping (2019) · Endocrine journal

Gegen Qinlian decoction ameliorates insulin resistance in type 2 diabetes: A systematic review and meta-analysis of RCTs with mechanistic insights into SIRT1/AMPK pathway activation.

Liao Yifan (2026) · Journal of ethnopharmacology · n=3247

Efficacy and Safety of Armolipid Plus®: An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Cicero Arrigo F G (2021) · Nutrients · n=1050

Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action.

Hu Shuangyuan (2022) · Pharmacological research

Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial.

Ji Linong (2025) · JAMA network open · n=113

Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes.

Nikseresht Mehdi (2024) · Physiological reports

Effects of a New Combination of Medical Food on Endothelial Function and Lipid Profile in Dyslipidemic Subjects: A Pilot Randomized Trial.

Landi Francesco (2019) · BioMed research international

Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₁ produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome.

Lamb Joseph J (2011) · Nutrition research (New York, N.Y.) · n=25

Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial.

León-Martínez Juan M (2021) · Journal of medicinal food · n=36

Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial.

Cicero Arrigo F G (2015) · Nutrition journal

[Therapeutic Effects of Berberine Capsule on Patients with Mild Hyperlipidemia].

Wang Li (2016) · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · n=97

Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients.

Marazzi Giuseppe (2011) · Advances in therapy · n=40

Adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomized controlled trial.

Chan MeiYan (2022) · Psychiatry and clinical neurosciences

The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment.

An Yuan (2014) · Clinical endocrinology

Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.

Beba Mohammad (2019) · Complementary therapies in medicine · n=5

Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Evans Malkanthi (2020) · Nutrients

Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial.

Rondanelli M (2023) · European review for medical and pharmacological sciences · n=24

Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials.

Vahedi-Mazdabadi Yasaman (2023) · Phytotherapy research : PTR · n=1600

The effect of berberine supplementation on obesity indices: A dose- response meta-analysis and systematic review of randomized controlled trials.

Xiong Pan (2020) · Complementary therapies in clinical practice

A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.

Wei Wei (2012) · European journal of endocrinology · n=31

Effects of dietary supplementations with the fibrous root of Rhizoma Coptidis and its main alkaloids on non-specific immunity and disease resistance of common carp.

Zhou Xia (2016) · Veterinary immunology and immunopathology

The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial.

Mansour Asieh (2025) · European journal of nutrition

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.

Yan Hong-Mei (2015) · PloS one

The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial.

Koperska Anna (2025) · Nutrients

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.

Zhao Miao-Miao (2021) · Nature communications

Does berberine impact anthropometric, hepatic, and metabolic parameters in patients with metabolic dysfunction-associated fatty liver disease? Randomized, double-blind placebo-controlled trial.

Koperska A (2024) · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes.

Guarino G (2017) · Journal of biological regulators and homeostatic agents

Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis.

Fang ShuangShuang (2022) · Journal of ethnopharmacology · n=1076

Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial.

Li Yan (2013) · Trials · n=120

A 13-week low glycemic load diet and lifestyle modification program combining low glycemic load protein shakes and targeted nutraceuticals improved weight loss and cardio-metabolic risk factors.

Dahlberg Clinton J (2017) · Canadian journal of physiology and pharmacology

Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial.

Panigrahi Antarmayee (2023) · BMC endocrine disorders · n=34

Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Zhao Jie V (2023) · The Journal of nutrition · n=1761

Effects of poly-bioactive compounds on lipid profile and body weight in a moderately hypercholesterolemic population with low cardiovascular disease risk: a multicenter randomized trial.

Solà Rosa (2014) · PloS one · n=102

Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial.

Moon Jessica M (2021) · Nutrients

The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials.

Asbaghi Omid (2020) · Clinical nutrition ESPEN

Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study.

Bandala Cindy (2024) · Nutrients

The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Guo Jing (2021) · Oxidative medicine and cellular longevity

Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study.

Ming Jie (2021) · Genome medicine · n=300

The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis.

Xue Chongxiang (2025) · Systematic reviews

Effect of a New Formulation of Nutraceuticals as an Add-On to Metformin Monotherapy for Patients with Type 2 Diabetes and Suboptimal Glycemic Control: A Randomized Controlled Trial.

Sartore Giovanni (2021) · Nutrients

Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials.

Ju Jianqing (2018) · Phytomedicine : international journal of phytotherapy and phytopharmacology · n=2147

Metabolic effect of berberine-silymarin association: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials.

Fogacci Federica (2019) · Phytotherapy research : PTR · n=497

Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion.

Pérez-Rubio Karina G (2013) · Metabolic syndrome and related disorders · n=24