Methylene Blue (low dose)

Also known as: MB, methylthioninium chloride, low-dose methylene blue

DDevelopmental142 studies referenced

Latest evidence update: 2008-03-01

Common dosage

Researched low doses: 0.5–4 mg/kg in animals; nootropic users self-dose 0.5–4 mg, but this is unvalidated

Description

Synthetic dye (FDA-approved as a drug for methemoglobinemia) being studied at low doses as a mitochondrial enhancer and nootropic. Animal and in-vitro work shows it can shuttle electrons in the electron transport chain and delay cellular senescence. No controlled human supplementation trials at nootropic doses.

Safety & interactions

Pharmaceutical-grade only — industrial dye is contaminated. Contraindicated with SSRIs/MAOIs (serotonin syndrome risk). G6PD deficiency precaution. Stains skin and urine blue-green.

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Order Methylene Blue (low dose)

Recommended: Researched low doses: 0.5–4 mg/kg in animals; nootropic users self-dose 0.5–4 mg, but this is unvalidated

Questions about Methylene Blue (low dose)

Are there any known interactions between Methylene Blue (low dose) and common medications?

How quickly does Methylene Blue (low dose) start working and should I cycle it?

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Referenced studies (2)

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