Probiotics

A meta-analysis of probiotic efficacy for gastrointestinal diseases

Krause Thilo (2012) · PLoS One · n=6352

Effects of probiotics on depressive symptoms: A meta-analysis

Cryan John F (2020) · Nutr Neurosci · n=1349

Prospective, Randomized, Double-Blind, Placebo-Controlled Study of an Oral Antioxidant-Rich Synbiotic Supplement on Skin Health and Photoaging.

Afzal Laila (2026) · Journal of cosmetic dermatology · n=36

Efficacy of probiotic supplementation for body weight management in overweight and obese adults: a meta-analysis of randomized controlled trials predominantly from East Asia.

Liu Shuying (2026) · Frontiers in public health · n=12

A randomized controlled trial of probiotics to reduce the severity of oral mucositis in patients with oropharyngeal carcinoma undergoing concurrent chemoradiotherapy.

Sojitra Saloni (2026) · Journal of cancer research and therapeutics · n=35

Effects of a Lactobacillus salivarius probiotic short-term intervention on S. mutans, Lactobacillus spp. and C. albicans - a randomized pilot study with pre-school children.

Staszczyk Małgorzata (2026) · Annals of agricultural and environmental medicine : AAEM

Risk of HSV-2 Acquisition Among Women with Bacterial Vaginosis: Systematic Review and Meta-Analysis.

Whitt Taylor N (2026) · Viruses · n=1906

Gut Microbiota Changes Following Short-Term Probiotic Supplementation in Older Home Enteral Nutrition Patients.

Tombolesi Niki (2026) · Nutrients

Synbiotic supplementation reduces intestinal permeability and inflammation in overweight or obese kidney transplant recipients: a randomized controlled trial.

Karimi Zeinab (2026) · Renal failure

Pharmacological and metabolic effects of Bifidobacterium triple viable capsules and Five-animal Play in patients with impaired glucose tolerance.

Yang Yu (2026) · Pakistan journal of pharmaceutical sciences

Effects of Nutritional Supplement Intake on Pregnancy Outcomes in Overweight and Obese Women: A Systematic Review and Meta-Analysis.

Chen Zezhen (2026) · The journal of obstetrics and gynaecology research · n=3482

JK5G postbiotics modulate gut microbiota and metabolome to alleviate cancer-related pain: a randomized controlled trial with multi-omics integration.

Chen Mengting (2026) · Frontiers in immunology · n=149

Lactobacillus-Based Microbiome Therapy for Acne Vulgaris: A GRADE Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Abedin Zain Ul (2026) · Journal of cosmetic dermatology · n=332

Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial.

Ratajczak Marzena (2026) · Frontiers in endocrinology · n=30

Green Tea Catechin Plus Inulin Improves Insulin Resistance Without Reducing Visceral Fat and Shows Exploratory Gut Microbiota Signals in Adults with Visceral Obesity: A Double-Blind Randomized Controlled Trial.

Iino Chikara (2026) · Nutrients · n=49

Probiotic-Driven Competitive Exclusion in the Human Gut: A Meta-Analysis of Microbial Diversity and Pathogen Suppression.

Alshatari Sumaya Sameer (2026) · Nutrients

Effect of Supplementation with Lactobacillus reuteri SGL 01 in Lactating Women on Breast Milk and Neonatal Gut Microbiota: An Exploratory, Randomized, Open-Label Clinical Trial.

Pagliarini Elia (2026) · Nutrients

Dietary Polyphenols as Modulators of Bifidobacterium in the Human Gut Microbiota.

Toderescu Corina Dalia (2026) · Nutrients

Decoding Links between Gut Microbiota and Metabolic-associated Fatty Liver Disease: Meta-analysis and Mediation Study Uncover Species-specific Taxa and a Novel Bile Acid Mediator.

Yi Xing Hao (2026) · Biomedical and environmental sciences : BES

Effect of Bifidobacterium longum on cognition and microbiota in post-stroke patients: a single-blinded, controlled trial.

Lin Shu-Ting (2026) · International journal of medical sciences · n=10

Vaginal and endometrial microbiota dysbiosis in patients with chronic endometritis: a systematic review and meta-analysis.

Wang Ruiying (2026) · Frontiers in cellular and infection microbiology · n=1274

Effect of Probiotic Supplementation on Reproductive Outcomes of Women With Polycystic Ovary Syndrome Who Are Candidates for Intrauterine Insemination: A Randomized, Double-Blind, Placebo-Controlled Trial.

Behroozilak Tahereh (2026) · Endocrinology, diabetes & metabolism · n=100

Effects of probiotic supplementation on immune and inflammatory markers in athletes: an umbrella review and re-analysis of published meta-analyses of randomised controlled trials.

Chen Lei (2026) · PeerJ · n=3413

Long-Term Efficacy of Limosilactobacillus reuteri DSM17938 in the Prevention of Functional Abdominal Pain Disorders.

Indrio Flavia (2026) · Nutrients

Evaluating the Efficacy of Probiotics on Inflammatory Cytokines in Alcoholic Liver Disease: A Focus on IL-6 and IL-10.

Bahetiyaer Jiadila (2026) · Nutrients

Effects of Heat-Killed Lactobacillus acidophilus IDCC 3302 on Skin Aging Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults.

Kim Hayoung (2026) · Nutrients · n=100

Efficacy and Safety of CO2 Laser Therapy Combined with Collagen Cream in Managing Vulvo-Vaginal Atrophy: A Randomized, Controlled Study on Symptom Relief and Microbiome Modulation.

Filippini Maurizio (2026) · Medicina (Kaunas, Lithuania)

Global Microbiome: Core and Unique Signatures Across Diverse Populations.

Huang Sherri (2026) · International journal of molecular sciences

Effect of bedrest on the human gut and oral microbiome: implications for frailty.

Alvaro-Fuss Monica (2026) · Experimental gerontology

A multi-strain probiotic formulation alleviates chronic constipation in middle-aged and older adults: A randomized, double-blind, placebo-controlled trial.

Xiao Rui (2026) · Clinical nutrition (Edinburgh, Scotland) · n=66

Interpheron type II signature in mucosal swabs of patient with infantile colic treated with Limosilactobacillus reuteri (L. reuteri) LMG P-27481.

Pau Anna (2026) · Cytokine

Probiotic Supplementation as an Adjuvant Therapy in Pediatric Drug-Resistant Epilepsy: A Double-Blind Placebo-Controlled Trial.

Rashdan Amira R (2026) · Pharmacotherapy · n=60

Weizmannia coagulans BC99 alleviates alcohol-induced oxidative stress and gut barrier dysfunction via modulation of butyrate metabolism: A randomized, double-blind, placebo-controlled trial.

Wang Yuxuan (2026) · Free radical biology & medicine

Novel Therapeutic Approaches for Treating Moderate-to-Severe Atopic Dermatitis in Infants with Polyvalent Allergic Sensitisation.

Lisiecka Maria Zofia (2026) · Journal of mother and child

Beneficial effects of Lactobacillus paragasseri OLL2716 on sleep homeostasis during psychological stress and poststress recovery in healthy adults: A randomized, double-blind, placebo-controlled study.

Yoshizawa Yuichi (2026) · Journal of dairy science

Impact of Subgingival Lactobacillus reuteri Probiotic Therapy on Clinical Outcomes and Porphyromonas gingivalis Quantification in Peri-Implant Disease: A Prospective RT-PCR-Based Clinical Study.

Kamalakannan Karthick (2026) · Journal of long-term effects of medical implants · n=26

Therapeutic Impact of Systemic Probiotics Combined with Mechanical Debridement in Peri-Implant Disease: A Clinical and Microbiological Evaluation.

Stella Blessy (2026) · Journal of long-term effects of medical implants · n=25

Safety and immune-regulating effects of Limosilactobacillus reuteri LR08: Preclinical and clinical evidence from a randomized controlled trial.

Han Mei (2026) · Clinical nutrition (Edinburgh, Scotland)

Probiotic Supplementation Reduces RRTIs and Enhances Gut Microbial and Immunity in Children: A Randomized Controlled Trial.

Chen Ke (2026) · Journal of microbiology and biotechnology

Probiotics and aging: Impacts on cognitive function, brain-derived neurotrophic factor, inflammation, and antioxidant activity. A systematic review and meta-analysis.

Handajani Yvonne Suzy (2026) · Journal of Alzheimer's disease : JAD

Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.

Li Yingmeng (2026) · mSystems · n=64

Effectiveness of probiotic supplementation in managing depressive symptoms and inflammatory status in patients with depression: A systematic review and meta-analysis.

Shakir Shakir Hajar Nabeel (2026) · Clinical nutrition (Edinburgh, Scotland)

A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort.

Allegretti Jessica R (2026) · Nutrients · n=350

Efficacy and Safety of CKDB-322, a Combination of Lactiplantibacillus plantarum Q180 and Phaeodactylum tricornutum, for Reducing Body Fat and Abdominal Adiposity in Overweight Adults.

Baek Hyang-Im (2026) · Nutrients · n=50

Efficacy of Specific Probiotic Strains in Subtypes of Irritable Bowel Syndrome: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Almalki Abdulrahman Saud (2025) · Medicina (Kaunas, Lithuania) · n=16

The vaginal microbiome of pregnant people living with HIV on antiretroviral therapy in the Democratic Republic of Congo: a pilot study and global meta-analysis.

Ndlovu Kimberley S (2026) · mSphere

Evaluating probiotic monotherapy in Helicobacter pylori infection: A meta-analysis of randomized controlled trials with trial sequential analysis.

Mishra Vivek (2026) · Microbial pathogenesis

Multi-Strain Probiotic and Common Infections in Early Childhood Education Settings: A Randomised Controlled Trial.

Ahmad Hafiz Haris (2026) · Journal of paediatrics and child health

Meta-analysis of the effects of probiotic supplementation on bone turnover markers in middle-aged and elderly patients with osteoporosis.

Yuan Yingjia (2025) · Frontiers in cellular and infection microbiology · n=1432

Vaginal chlorhexidine gluconate versus fluconazole for recurrent vulvovaginal candidiasis: A randomized noninferiority trial.

Alvendal Cathrin (2026) · PloS one · n=11

Maternal and infant microbiota in early infancy: Longitudinal findings from a randomised controlled trial.

Yu Jinyue (2026) · Journal of pediatric gastroenterology and nutrition

Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis.

Barac Branko (2025) · Journal of infection in developing countries · n=100

Oral Probiotic Containing Streptococcus salivarius K12 and Lactobacillus brevis CD2 for Preventing Bacterial Pneumonia in Severe COVID-19: Randomized Clinical Trial.

Lauxen Jonathan R (2025) · The journal of contemporary dental practice · n=60

School-Age Neurodevelopmental and Atopy Outcomes in Extremely Preterm Infants: Follow-Up from the Single Versus Triple-Strain Bifidobacterium Randomized Controlled Trial.

Athalye-Jape Gayatri (2026) · Nutrients

Effects of a novel synbiotic intervention on abdominal visceral fat reductions and gut microbiota in overweight and obese adults: A randomized, double-blind, placebo-controlled trial.

Li Nengjuan (2026) · Clinical nutrition (Edinburgh, Scotland) · n=112

Probiotic, Prebiotic, or Synbiotic Supplementation in Parkinson's Disease: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.

Cabanillas-Lazo Miguel (2026) · Gerontology · n=12

Efficacy of probiotic and synbiotic supplementation on the length of hospital stays and risk of postoperative mortality in patients undergoing surgery: an umbrella review of systematic reviews and meta-analyses of randomized clinical trials.

Mazinani Kimia (2026) · European journal of medical research · n=6378

The Role of Probiotics in Depression and Quality of Life in Patients with Irritable Bowel Syndrome.

Erlita Diana (2025) · Acta medica Indonesiana · n=35

Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.

Ben Fredj Sihem (2026) · BMC psychology · n=3350

Lactobacillus, vitamin C, cranberry and hibiscus versus placebo for prolonging the latency period of premature rupture of membranes: a double-blind randomized clinical trial.

Portillo Gonzales Iris Janeth (2026) · European journal of obstetrics, gynecology, and reproductive biology · n=84

Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials.

Éliás Anna Júlia (2026) · BMC medicine

Antimicrobial effect of garlic-based mouthwash on dental caries-related oral microorganisms: A systematic review and meta-analysis.

de Oliveira Alves Renata (2026) · Archives of oral biology

A 16S rRNA-based meta-analysis of gut microbiota in diabetic nephropathy using QIIME2 and publicly available NGS datasets.

Chopra Chahat (2026) · Computational biology and chemistry

Bioconversion-Based Postbiotics Enhance Muscle Strength and Modulate Gut Microbiota in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial.

Jung Seung Hyeon (2025) · Nutrients

Oral Probiotics in Acne vulgaris: A Systematic Review and Meta-Analysis of Double-Blind Randomized Clinical Trials.

Tjiu Jeng-Wei (2025) · Medicina (Kaunas, Lithuania) · n=231

Weizmannia coagulans BC01 supplementation improved functional constipation by regulating gut microbiota: A randomized, placebo-controlled, clinical study.

Xu Yihui (2025) · Medicine · n=79

Impact of fiber-containing enteral nutrition on microbial community dynamics in critically ill trauma patients: a pilot-randomized trial.

Serbanescu Mara A (2025) · BMC medicine · n=17

Probiotic and synbiotic supplements for osteoporosis: a meta-analysis of randomized trials.

Gong Zhiyuan (2025) · Journal of health, population, and nutrition

Probiotic Supplementation and Executive Function in Children With Attention-Deficit/Hyperactivity Disorder.

Parhiz Abdolrahman (2026) · Neuropsychopharmacology reports

Effects of probiotic supplementation on intestinal microbiota in patients with diabetes/prediabetes: a systematic review and meta-analysis of randomized controlled trials.

Hong Lifen (2026) · The British journal of nutrition · n=1113

The role of microbiome-modulating supplements in managing metabolic syndrome risk factors among overweight and obese youth: a GRADE-assessed meta-analysis.

Xie Jiamin (2025) · BMC pediatrics

The effect of probiotic supplementation during pregnancy on pregnancy complications: An umbrella meta-analysis.

Gao Qian (2025) · Medicine · n=83817

Randomized, placebo-controlled trial reveals the impact of dose and timing of Bifidobacterium infantis probiotic supplementation on breastfed infants' gut microbiome.

O'Brien Claire E (2026) · mSphere · n=40

Oral Lacticaseibacillus rhamnosus GG Exposure During Pregnancy and Effects on Maternal Inflammatory Response-A Blinded, Pilot Randomized, Placebo-Controlled Study.

Nordqvist Mahsa (2025) · American journal of reproductive immunology (New York, N.Y. : 1989) · n=40

Role of Probiotics in Management of Depressive Symptoms and Cognitive Impairment in Patients With Depression: An Updated Analysis of Trials.

Arsal Syed Ali (2025) · Brain and behavior

Unraveling gut microbiome interferences in cancer immunotherapy: a meta-analysis of diverse drug effects.

Xu Jiaqiang (2025) · BMC cancer · n=22568

The impact of gut microbiota modulation on responses to immune checkpoint inhibitors in cancer.

Ni Zheying (2026) · Acta microbiologica et immunologica Hungarica · n=5642

Increasing Phytochemical-rich Foods and Lactobacillus Probiotics in Men with Low-risk Prostate Cancer-A Randomised, Double-blind, Placebo-controlled Trial.

Thomas Robert J (2026) · European urology oncology · n=208

Effects of home-based exercise training on gut microbiota and possible relations with cognitive function and metabolic health in postmenopausal women with type 2 diabetes mellitus: a randomized control trial.

Vahed A (2025) · Diabetes research and clinical practice

Clinical Effects of Lactobacillus reuteri on Gingival Inflammation and Alveolar Bone Loss in Periodontitis.

Lu Jian (2025) · Oral health & preventive dentistry · n=84

Evaluating the bifidogenic effect of various infant formula supplementations: a systematic review and network meta-analysis of randomized controlled trials.

Mansouri Fatemeh (2025) · Journal of developmental origins of health and disease

Microbiome dynamics in attention-deficit hyperactivity disorder: A systematic review and meta-analysis decoding the role of gut dysbiosis and potential dietary interventions.

Ghosh Sourav (2026) · European child & adolescent psychiatry

Randomized clinical trial of vaginal microbiota in menopausal genitourinary syndrome using radiofrequency and topical estriol.

Zunino Ana Ximena (2025) · Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

Impact of vaginal microbiota on the clinical efficacy and long-term recurrence of ketoconazole suppositories in treating severe vulvovaginal candidiasis: a secondary analysis of a multicentre randomised trial.

Mi Lan (2025) · Frontiers in cellular and infection microbiology · n=253

Bifidobacterium animalis subsp. lactis Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis.

Wang Kexin (2025) · mSystems · n=37

Efficacy and Safety of <em>Saccharomyces Boulardii</em> with Standard Quadruple Therapy for Eradication of <em>Helicobacter Pylori </em>in Adults: Meta-Analysis.

Ma Fengzhen (2025) · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP · n=2295

The effect of probiotic consumption on fatigue severity and sexual function among postmenopausal women: a double-blind randomized controlled trial in the west of Iran.

Kazemi Farideh (2026) · Menopause (New York, N.Y.) · n=40

Gut microbiome dysbiosis in chronic lung disease: a systematic review and meta-analysis.

Pan Juan (2025) · Frontiers in cellular and infection microbiology · n=7

Yiqi Huayu Jiedu decoction enhances pathological response in neoadjuvant chemotherapy-treated gastric cancer patients: A prospective, randomized controlled trial.

Xu Shuo (2025) · Phytomedicine : international journal of phytotherapy and phytopharmacology · n=122

Dietary Supplementation with the Probiotic Bacillus velezensis BV379 Decreases Abdominal Bloating Without Perturbing the Commensal Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults.

Garvey Sean M (2026) · Journal of the American Nutrition Association

Efficacy of non-ablative vaginal erbium laser for rUTI prevention in postmenopausal women.

Zheng Jiqiong (2025) · Lasers in medical science

Multi-omics analysis of a prebiotic intervention with pectin in lipid transfer proteins (LTPs) allergic patients.

Gómez Francisca (2025) · Carbohydrate polymers

Blueberry Consumption in Early Life and Its Effects on Allergy, Immune Biomarkers, and Their Association with the Gut Microbiome.

Venter Carina (2025) · Nutrients · n=30

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis.

Rokkas Theodore (2026) · European journal of gastroenterology & hepatology · n=3154

Probiotic Lactiplantibacillus plantarum Probio87 Improves Gut Microbial Profiles in HPV-Positive Women: A Randomized, Placebo-Controlled and Double-Blind Study.

Xu Pei (2025) · Molecular nutrition & food research

Circulating Short-Chain Fatty Acids: Association with Vaginal Microbiota, Genital Inflammation, and HIV Acquisition.

Shivakoti Rupak (2025) · AIDS research and human retroviruses · n=99

Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial.

Ravel Jacques (2025) · NPJ biofilms and microbiomes

Novel Application of Oral Postbiotics for Skin Condition in Healthy Middle-Aged Women: A Randomized, Double-Blind, and Placebo-Controlled Study.

Sawashita Jinko (2025) · Journal of cosmetic dermatology

The effects of next generation probiotics on metabolic dysfunction-associated steatotic liver disease: a parallel, double-blind, randomized, placebo-controlled trial.

Won Sung-Min (2025) · Journal of translational medicine · n=110

Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial.

Starck Edouard (2025) · Nutrients

Gut microbiota and immune regulation by Lactobacillus delbrueckii subsp. bulgaricus LB42: From preclinical safety assessment to clinical evidence.

Wang Jingyan (2026) · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

The Effect of Heat-Killed Lacticaseibacillus paracasei K71 on Abdominal Fat Reduction: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial.

Yamamoto-Yamaya Kana (2025) · Journal of nutritional science and vitaminology

Breastfeeding, the Gut Microbiome, and Growth among Infants in Lusaka, Zambia.

Lauer Jacqueline M (2025) · The Journal of nutrition · n=247

Bifidobacterium animalis subsp. lactis TISTR 2591 Improves Glycemic Control and Immune Response in Adults with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial.

Khiaolaongam Wiritphon (2025) · Nutrients

Probiotics and Synbiotics Supplementation Reduce Inflammatory Cytokines in Individuals with Prediabetes and Type 2 Diabetes Mellitus: Findings from a Systematic Review Meta-analysis.

Setayesh Azin (2025) · Advances in nutrition (Bethesda, Md.) · n=1321

The mechanism of probiotics in pregnancy outcomes in overweight or obese pregnant women based on meta-analysis, network pharmacology and molecular docking.

Zhong Ting (2025) · BMC pregnancy and childbirth · n=1563

Meta-analysis of H. pylori and the gut microbiome interactions and clinical outcomes.

Wu Xiongjian (2025) · Frontiers in cellular and infection microbiology

The promising effects of a multi-species synbiotic preparation on metabolic profile in elderly patients with type 2 diabetes and high cardiovascular risk: a randomized, triple-blind, placebo-controlled trial.

Dolatkhah Neda (2025) · Nutrition & diabetes

The Role of the Oral Microbiome in Periodontal Disease: A Systematic Review of Microbial Associations and Therapeutic Implications.

Alavi Seyed Ebrahim (2025) · Current microbiology

Efficacy and safety of probiotic supplements on cognitive function: a systematic review and meta-analysis of randomized clinical trials.

Calzada-Gonzales Nancy (2025) · BMC complementary medicine and therapies · n=2390

Efficacy of probiotics and synbiotics combined with phototherapy vs phototherapy alone in neonatal hyperbilirubinemia: a systematic review and meta-analysis of randomized controlled trials.

Fatima Marhaba (2025) · European journal of pediatrics

Brain-gut-microbiota axis: An effective target of abdominal acupuncture therapy for post-stroke functional constipation.

Li Sicheng (2025) · Complementary therapies in medicine

The Effects of the Crohn's Disease Exclusion Diet (CDED) Alone Versus CDED Plus Partial Enteral Nutrition (PEN) on Gut Microbiome Composition in Pediatric CD Patients.

Rohani Pejman (2025) · MicrobiologyOpen

Probiotics in Term Infants: Clinical Impact of Infant-Type Bifidobacteria: A Systematic Review and Meta-analyses.

Sjælland Mathias A (2025) · The Journal of nutrition

Probiotics and dietary fibre fermented milk supplementation initiated in the first trimester to prevent gestational diabetes mellitus in overweight and obese pregnant women: A randomized controlled trial.

Zhang Lirui (2025) · Diabetes, obesity & metabolism · n=478

Probiotics for preventing neonatal sepsis in preterm neonates: a systematic review and meta-analysis for clinical practice.

Maulida Rizka (2025) · Epidemiology and health

Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial.

Napier Brooke A (2025) · Nutrients · n=32

Microbiota-Dependent Fiber Responses: A Proof-of-Concept Study on Short-Chain Fatty Acid Production in Prevotella- and Bacteroides-Dominated Healthy Individuals.

Bartsch Madeline (2025) · The Journal of nutrition

Meta-analysis of the association between gut microbiota and postpartum depression.

Guo Yan (2025) · Journal of psychosomatic obstetrics and gynaecology

[Effects of Yiqi Huoxue Jiedu formula on the gut microbiota in elderly patients with pulmonary-derived sepsis based on 16S rDNA sequencing: a multicenter prospective randomized double-blind controlled trial].

Chen Rui (2025) · Zhonghua wei zhong bing ji jiu yi xue · n=2021

Effects of Probiotic and Synbiotic Supplementation on Glycemic Indices in Adult Individuals with Prediabetes and Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose-Response Meta-analysis of RCTs.

Setayesh Azin (2026) · Probiotics and antimicrobial proteins

Daily mango (Mangifera indica L.) consumption supplemented with probiotics differentially modulates inflammation and cognitive function in individuals with overweight or obesity: a placebo-controlled, double-blind, and randomized trial.

Kim Hyemee (2026) · Food & function

Ovovid trial: the effect of a probiotic micronutrients supplement on oocyte retrieval and quality in oocyte donors. A double blind, randomized controlled trial.

Bontá Silvia (2026) · Journal of assisted reproduction and genetics

Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial.

Lawrence Kate (2025) · BMC psychiatry

Effectiveness of probiotic supplements on cognitive function in mild cognitive impairment and Alzheimer's disease: A meta-analysis of randomized controlled trials.

Peng Tzu-Rong (2025) · General hospital psychiatry · n=994

A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention.

Vega-Abellaneda Sara (2025) · Liver international : official journal of the International Association for the Study of the Liver · n=29

Effects of a Four-Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial.

Leta Valentina (2025) · Movement disorders : official journal of the Movement Disorder Society · n=74

Gut microbiota, probiotics, and migraine: a clinical review and meta-analysis.

Grodzka Olga (2025) · Journal of oral & facial pain and headache

Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety.

Thabane Alex (2025) · Trials · n=568

Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial.

Mensi Magda (2025) · Clinical oral investigations

Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer's disease: a randomized, double blind, placebo controlled trial.

Jouni Nagham (2025) · Scientific reports · n=60

Impact of prebiotics and postbiotics in the management of constipation: Analysis of their differentiated modulation of intestinal microbiota.

Culqui Lévano Dante Roger (2025) · Clinical nutrition ESPEN · n=24

Effect of probiotic supplementation on the progression of non-cavitated carious lesions in children: A 12-month randomized controlled trial.

Ibacache Rodrigo Cabello (2026) · European journal of oral sciences

Efficacy of the Combination Therapy of Intense Pulsed Light and Microneedling With a Postbiotic Formulation for Melasma.

Li Zhanhong (2025) · Journal of cosmetic dermatology

Interindividual variability in gut microbiome mediates the efficacy of resistant starch on MASLD.

Long Xiaoxue (2025) · Cell metabolism

Inulin-induced improvements on bowel habit and gut microbiota in adults with functional constipation: findings of a randomized, double-blind, placebo-controlled study.

Puhlmann Marie-Luise (2025) · BMC gastroenterology · n=39

Novel formulated food for the elderly regulates specific gut bacterial taxa and improves host physiology.

Xiao Yue (2025) · Food research international (Ottawa, Ont.)

Effect of orally administered L. crispatus M247 in favoring HR-HPV clearance and CST shift: results from a randomized, multi-center, placebo-controlled trial.

Di Pierro Francesco (2025) · Scientific reports · n=62

12-week preoperative probiotic supplementation versus placebo: effects on inflammation, endotoxemia, adipokines, and gastrointestinal peptides in patients six months after bariatric surgery - a double-blind, randomized, placebo-controlled clinical trial.

Potrykus Marta (2025) · Nutrition journal · n=110

Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study.

Nishikawa Yuriko (2025) · Nutrients · n=59

One-year clinical and radiographic evaluation of young permanent molars treated with brix 3000 vs. papacárie duo: a randomized controlled clinical trial.

Hassanein Passant H (2025) · BMC oral health

Association Between Gut Microbiota and Pneumonia Risk: A Systematic Review and Mendelian Randomization.

Deng Qingping (2025) · International journal of medical sciences · n=32748274

A Prebiotic-Supplemented Formula Improves Gut Microbiota and Intestinal Inflammatory Microenvironment in Patients with Colorectal Adenoma: A Double-Blind, Placebo-Controlled Trial.

Meng Sijia (2025) · The Journal of nutrition · n=51

Assessment of the role of probiotics in prevention of ventilator-associated pneumonia in neonates.

Khodair Hager Ahmed (2025) · European journal of pediatrics

The Effect of Lactobacillus Acidophilus (La5) on the Incidence of Urinary Tract Infection in the Puerperium: A Randomized Placebo-Controlled Trial.

Borhani Fatemeh (2026) · Probiotics and antimicrobial proteins

Effects of Probiotics and Synbiotics Supplementation on Blood Pressure in Adults with Prediabetes and Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis.

Setayesh Azin (2026) · Probiotics and antimicrobial proteins · n=1281

Lactobacillus gasseri CECT 30648 shows probiotic characteristics and colonizes the vagina of healthy women after oral administration.

Perez Marta (2025) · Microbiology spectrum · n=45

Decadal Meta-Analysis Confirms Bacillus spp. Optimizes Fish Intestinal Microbiota.

Yang Qing (2026) · Annals of the New York Academy of Sciences

Modulating the lung-gut axis: A randomized controlled trial of Xie Bai Zeng Ye decoction on intestinal flora and mucosal immunity in children with post-infectious cough.

Luo Jing (2025) · Medicine

[Acupoint application therapy for diarrhea-predominant irritable bowel syndrome with spleen deficiency and dampness retention: a randomized controlled trial].

Mei Xiao (2025) · Zhen ci yan jiu = Acupuncture research · n=88

Probiotic Supplementation Enhances the Effects of a Nutritional Intervention on Quality of Life in Women with Hashimoto's Thyroiditis-A Double-Blind Randomised Study.

Osowiecka Karolina (2025) · Nutrients · n=32

Probiotic Supplementation and Bone Health Parameters in Adults: A Systematic Review and Meta-Analysis.

Hidayat Khemayanto (2026) · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial.

Manerkar Mayura (2025) · BMC oral health

Meta-analytical insight on probiotic metabolites and inflammatory markers in diabetes.

Xie Yanpeng (2025) · Frontiers in cellular and infection microbiology · n=46

Can Probiotics Influence Adaptive Thermogenesis Induced by Continuous Energy Restriction after a 12-Week Intervention in Adult Males Living with Obesity? A Secondary Analysis of a Randomized Clinical Trial (São Paulo Clinical Study of Obesity and Intestinal Microbiota).

Ferracini Catarina Bortoloto França (2025) · The Journal of nutrition · n=25

The effect of probiotics on weight management in patients with severe obesity undergoing metabolic and bariatric surgery: a systematic review and meta-analysis.

Wang Shi (2025) · Annals of medicine · n=693

Effects of Probiotics on Markers of Oxidative/Nitrosative Stress and Damage Associated with Inflammation in Non-communicable Diseases: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials.

Silva Natanny Swerts (2026) · Probiotics and antimicrobial proteins · n=807

Effectiveness of Lactobacillus therapy in women with cervical human papillomavirus infection: A systematic review and meta-analysis.

Susetiati Devi Artami (2025) · The Journal of international medical research · n=326

Investigating the Effect of Synbiotic and SperiGen Supplementations on Spermatogram in Idiopathic Oligoasthenoteratozoospermia: A Double-Blinded Randomized Clinical Trial.

Zarehoroki Ali (2026) · International journal of urology : official journal of the Japanese Urological Association · n=73

Exploring the causal relationship between acute respiratory distress syndrome and gut microbiota: Unveiling the gut-lung axis through a large-scale Mendelian randomization study.

Li Cong (2025) · Medicine

Preventive effects of combined live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus cereus tablets on radiation pneumonitis-associated with cyberknife treatment for pulmonary malignancies.

Wang Wei (2025) · Annals of clinical microbiology and antimicrobials · n=130

Gut Microbiota and Central Nervous System Tumors: A Comprehensive Systematic Review and Meta-Analysis of Microbiome-CNS Interactions.

Nowacka Agnieszka (2025) · International journal of molecular sciences · n=387

Maternal-to-neonatal microbial transmission and impact of prenatal probiotics on neonatal gut development.

Meng Lulu (2025) · Journal of translational medicine

Effects of konjac glucomannan on gastrointestinal symptoms and gut microbiota in athletes with functional constipation: a double-blind randomized controlled trial.

Zhu Yuping (2025) · European journal of nutrition

The impact of very-low-calorie ketogenic diets on gut microbiota in individuals with obesity: a systematic review and meta-analysis.

Wang Shun (2025) · Gut microbes

Resilience of the Gut Microbiome to Short Proton Pump Inhibitor Therapy With or Without High-Dosage L. reuteri in H. pylori-Infected Adults.

Bibbò Stefano (2025) · Helicobacter · n=26

Can pre-/pro and synbiotics affect cardiovascular risk factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.

Wu Yunduo (2025) · Obesity research & clinical practice

Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials.

Lele Juan Ajmn (2025) · Narra J · n=1058

Limosilactobacillus reuteri CCFM1388 Enhances Exercise Endurance by Modulating Intestinal Bile Acid Metabolism and Cholesterol Absorption.

Wen Xin (2025) · Molecular nutrition & food research

Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.

Nieto Pamela A (2025) · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

Effects of enteral nutrition protocols on nutritional indicators and prognosis in neurological ICU patients: a randomized controlled trial.

Zhang Xia (2025) · Scientific reports · n=100

Study on the mechanism of Fuzi Lizhong decoction in the treatment of colorectal cancer of spleen kidney deficiency from the perspective of intestinal flora and hypoxia inducible factor-1α signalling pathway.

Lina Zhang (2025) · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · n=50

Probability of vertical HIV transmission: a systematic review and meta-regression.

Walters Magdalene K (2025) · The lancet. HIV

EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTS.

DE Souza Gabriel Caio (2025) · Arquivos de gastroenterologia · n=28

A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Benefits of Using Lactobacillus Supplements as an Adjunct Treatment for Helicobacter pylori Eradication.

Azam Asma (2025) · MicrobiologyOpen · n=2054

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial.

Ghoshal Uday C (2026) · Journal of gastroenterology and hepatology

Weizmannia coagulans BC99 regulates oxidative stress and serum metabolic pathways to improve allergic rhinitis: a randomized, double-blind, placebo-controlled trial.

Li Xuan (2025) · Frontiers in immunology · n=40

Efficacy and Safety of Lactobacillus delbrueckii subsp. lactis CKDB001 Supplementation on Cognitive Function in Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Baek Hyang-Im (2025) · Nutrients · n=50

Comparison with healthy controls: meta-analysis of changes in intestinal flora in Chinese patients with irritable bowel syndrome.

Tu Hao (2025) · Frontiers in cellular and infection microbiology

Research progress of probiotics intervention on reconstruction of intestinal flora and improvement of quality of life in patients after endometrial cancer surgery.

Chen Wei (2025) · Frontiers in cellular and infection microbiology · n=1246

Meta-analysis of probiotic metabolites in the prevention of gestational weight gain and postpartum weight retention.

Jia Xuyue (2025) · Frontiers in cellular and infection microbiology · n=46

The efficacy of lactobacillus reuteri in conjunction with racecadotril in managing pediatric rotavirus enteritis and its impact on intestinal mucosa and immune function.

He Zhihua (2025) · African health sciences

A Low-Gluten Diet Reduces the Abundance of Potentially Beneficial Bacteria in Healthy Adult Gut Microbiota.

Delmas Eve (2025) · Nutrients

Probiotic Supplementation Can Alter Inflammation Parameters and Self-Reported Sleep After a Marathon: A Randomized, Double-Blind, Placebo-Controlled Study.

Aquino-Lemos Valdir (2025) · Nutrients · n=14

The effect of probiotic supplementation on sexual function in premenopausal and menopausal women: a randomized controlled clinical trial.

Valizadeh Roghayyeh (2025) · Scientific reports

Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal status, oxidative stress, and clinical symptoms in women with polycystic ovary syndrome: a randomized clinical trial.

Shirani Mahsa (2025) · Nutrition journal · n=90

Weizmannia coagulans BC99 alleviates pediatric allergic rhinitis via the gut microbiota-SCFAs- immunomodulatory axis: A randomized, double-blind, placebo-controlled trial.

Han Zhidong (2026) · International immunopharmacology

Non-Digestible Oligosaccharides and Constipation: A Systematic Review and Meta-Analysis of Randomized Trials on Stool Frequency, Stool Consistency, and Fermentation Biomarkers.

Chen Huiyu (2025) · Nutrients · n=1786

The effects of Bifidobacterium animalis subsp. lactis BLa80 on glycemic control and gut microbiota in patients with T2DM: a randomized, double-blind, placebo-controlled trial.

Zhao Chao (2025) · Journal of diabetes and its complications · n=80

Probiotics for pediatric diarrhea and constipation: an umbrella meta-analysis.

Chen Le (2025) · BMC pediatrics

Time-stratified microbial colonization in passive self-ligating, active self-ligating, and conventional brackets: A systematic review and meta-analysis.

Singaraju Gowri Sankar (2025) · Journal of the World federation of orthodontists · n=751

Effects of a Novel Probiotic Supplement with Weight Gain Intervention on Anthropometry, Body Composition, and Appetite in Underweight Adults: A Randomized Controlled Trial.

Hatami Alireza (2025) · Journal of dietary supplements · n=47

Effects of Two Compound Probiotic Formulations on Gastrointestinal Symptoms and Gut Microbiota: A 4-Week Randomized, Double-Blind Intervention Trial.

Qu Zhen (2025) · Nutrients

Treatment modalities for metabolic dysfunction-associated steatotic liver disease (MASLD) in children and adolescent: A systematic review and meta-analysis of randomized controlled trials.

Zaidi Syed Muhammad Mehdi (2025) · Clinics and research in hepatology and gastroenterology · n=1722

Lacticaseibacillus rhamnosus GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients.

De Boeck Ilke (2025) · Microbiology spectrum · n=33

Can probiotics reduce chemotherapy-induced complications in leukemia patients? A systematic review and meta-analysis of randomized controlled trials.

Chen Miaomiao (2026) · Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · n=753

Probiotics Prevent Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomised Controlled Trial.

Quan Xin (2025) · Liver international : official journal of the International Association for the Study of the Liver · n=142