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Creatine Monohydrate

Also known as: creatine, creatine mono

SStrong Evidence95/10054 studies referenced

Common dosage

3-5g daily

Category

amino acid

Description

One of the most researched supplements in existence. Improves exercise performance, muscle recovery, and has emerging evidence for cognitive benefits under sleep deprivation.

Safety & interactions

Safe for long-term use. Stay hydrated. No loading phase needed — 5g daily reaches saturation in ~3 weeks.
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What the research shows

Increases muscle strength and power performance in resistance-trained athletes

Reduces fatigue and accelerates recovery from resistance exercise

Enhances muscle mass and body composition when combined with resistance training

May reduce depressive symptoms and improve depression remission rates in people with clinical depression

May improve subjective sleep quality and promote earlier bedtime

moderate evidence1 study:Nutrients (2025)

Improves focus and attention on cognitive tests

emerging evidence1 study:Nutrients (2025)

Does not significantly affect how hard exercise feels or total sleep time

moderate evidence1 study:Nutrients (2025)

Researched health areas

Health domains where Creatine Monohydrate has published research. Click any domain to see all supplements and habits for that area.

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Questions about Creatine Monohydrate

Studies on Creatine Monohydrate (54)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.